Hormone Metabolism & How to Improve It Naturally

Hormone Metabolism & How to Improve It Naturally

Hormone metabolism (hormone breakdown and excretion) is the process the body uses to eliminate hormones from your body.

Why is it so important? 

If you don't break down and excrete hormones completely, then they're reabsorbed into the bloodstream via the digestive system. This can create a two- or three-fold effect of these hormones since hormones are messengers.

Hormones tell the body what to do at certain times. In the case of oestrogen, it tells the body to build cells and prepare for ovulation. If the message is constantly stimulatory, then tissue overgrowth, fibroids, fluid retention, weight gain, bleeding and mood issues may develop.

Most chronic hormonal conditions do not metabolise hormones well, either due to genetic influences or lifestyle factors. Alcohol, for example, increases circulating hormones by 200% because the liver focuses primarily on alcohol metabolism, before hormone metabolism. Sugar has a similar effect in damaging the liver.

Women with endometriosis and PCOS will generally have a genetic predisposition to poor hormone metabolism. When they discover the exact gene they can call it the Dr Jeff gene. They haven't found it yet, but they will eventually.

Perimenopausal women are particularly prone to elevated oestrogen levels because progesterone naturally reduces five years before menopause. This leaves oestrogen unopposed, which is the primary trigger for heavy bleeding.

Replacing progesterone is a band-aid approach and leaves the body further unable to produce its own progesterone, which can lead to difficult menopause. It's far better to encourage the body to produce its own progesterone via the adrenals, which is the natural process. 


The liver is the first stop for hormone metabolism. Hormones are secreted into the blood to act as messengers. They circulate within the blood looking for hormone receptor sites to bind to. The body secretes different hormones at different times of the day, times of the cycle and during life-events such as puberty, pregnancy and menopause. These hormones should then pass through the liver and get broken down into smaller metabolites, to be further broken down and excreted via the digestive system.

There are three main detox pathways in the liver. Methylation, conjugation and glycination. Hormones mainly go through a process of methylation and conjugation. 

Many women also have the MTHFR gene which reduces their ability to methylate in the liver.

Liver metabolism

We often see women with compromised liver function and fatty livers, without any history of alcohol use. The primary reason for this is the hidden sugar in food. It's very easy to ingest 50 to 100 teaspoons of sugar a day without even realising it. This amount of sugar damages the liver, just as much as excessive alcohol intake.

There are many natural medicines to assist in improving liver function. Well-known herbal medicines such as Milk Thistle, Dandelion and Globe artichoke have been used by naturopaths for decades to stimulate liver function. Happy liver contains these three important herbal medicines for liver function.

One of the most effective natural remedies, however, is Di-Indol-Methane (DIM). This naturally occurring compound is found in cruciferous vegetables and is especially high in Broccoli sprouts. Having a green juice every day can help, and you can get DIM in supplement form. Our approach is to to use a supplement combination of DIM, Broccoli and Calcium D-Glucarate which can assist the body in clearing hormones effectively.


Once the liver has broken the hormones down into smaller molecules the role of the digestive system is to further break down and eliminate these hormones, otherwise they can be resorbed back into the blood supply. If the liver doesn't fulfil its role and neither does the digestion, then we find the double and triple impact of these hormones.

Synthetic hormones are particularly hard to break down and it has been postulated that the number of women taking hormones which end up in the water supply, is impacting the fertility of animals, and even men.

The process is not just elimination, however. The diversity of your microbiome plays an important role. Over 60 intestinal bacteria have been identified and classified into what has been named the estrobolome (bacteria which influence oestrogen levels).

Research is still very new; however, these bacteria have been shown to affect levels of Beta-glucuronidase and glucosidase which either increase or decrease absorption of oestrogen in the gut. Although not identified, the same process would apply to all hormones that the body produces.

Interestingly, diet has an impact on the level of activity of these enzymes. A diet high in protein has been shown to increase the level of circulating oestrogen, while a plant-based diet feeds the beneficial bacteria which lower circulating oestrogen.


If you don't metabolise hormones efficiently, then these non-metabolised hormones go on to have a secondary influence, which not only affects tissues but confuses your hormone control centre. If you take synthetic hormones as well, it's a recipe for disaster for your endocrine system. This is one of the main reasons why so many women have thyroid, adrenal and sugar issues. The body is connected in every way.

Happy Hormones assists the body to reconnect the hormone control centres, but if you have issues breaking down and metabolising hormones, then the Happy DIM will assist you with this. Nothing replaces a healthy plant-based diet, but the combination of these two produces is the most effective way to treat hormonal issues.

Virtually every hormonal condition before menopause can benefit from this combination. The two products represent the leading edge in helping women. Every other product and approach is either making matters worse or just touching the edges of the underlying issues. Our advice and approach have been successful with so many women – you can read the thousands of positive reviews on our Reviews section


 Jeff Butterworth


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